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In this review, we provide a comprehensive analysis of recent clinical trials evaluating platinum-based combination strategies (excluding radiotherapy) and give an overview of trial concepts that will lead to more refined therapies for cancer

Carbon dots for the treatment of inflammatory diseases: An appraisal of in vitro and in vivo studies

10.1161/STROKEAHA.116.015609 Summary Keywords CHAC1, CHAC2, glutathione, ferroptosis, cancer, BOTCH, endoplasmic reticulum stress Citation Schrder E, Jalilvand TV, Kahl J, Kaiser CS and Liebau E (2025) The strategic breakdown: CHAC enzymes as regulators of glutathione homeostasis and disease implications

Offering support for this hypothesis, we find that joint treatment of HT22 cells with SMT (an iNOS inhibitor 47 ) exerts a stronger protection against erastin/RSL3-induced ferroptotic cell death in HT22 cells than does CPZ (an nNOS inhibitor 46 )

In SLE, dysregulated autophagy contributes to immune hyperactivation, defective apoptotic cell clearance, and increased autoantigen availability

We found an average 16-fold increase in the CALR GP level 1 week after completion of 4-week intermittent fasting compared with the level before 4-week intermittent fasting